作者
Jennifer N Walker, Ana L Flores-Mireles, Chloe L Pinkner, Henry L Schreiber IV, Matthew S Joens, Alyssa M Park, Aaron M Potretzke, Tyler M Bauman, Jerome S Pinkner, James AJ Fitzpatrick, Alana Desai, Michael G Caparon, Scott J Hultgren
发表日期
2017/10/10
期刊
Proceedings of the National Academy of Sciences
卷号
114
期号
41
页码范围
E8721-E8730
出版商
National Academy of Sciences
简介
Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of catheter-associated urinary tract infection (CAUTI), which frequently progresses to more serious invasive infections. We adapted a mouse model of CAUTI to investigate how catheterization increases an individual’s susceptibility to MRSA UTI. This analysis revealed that catheterization was required for MRSA to achieve high-level, persistent infection in the bladder. As shown previously, catheter placement induced an inflammatory response resulting in the release of the host protein fibrinogen (Fg), which coated the bladder and implant. Following infection, we showed that MRSA attached to the urothelium and implant in patterns that colocalized with deposited Fg. Furthermore, MRSA exacerbated the host inflammatory response to stimulate the additional release and accumulation of Fg in the urinary tract, which facilitated MRSA …
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JN Walker, AL Flores-Mireles, CL Pinkner… - Proceedings of the National Academy of Sciences, 2017