作者
Adrienne S McCampbell, Megan L Mittelstadt, Ruhee Dere, Sunam Kim, Lijun Zhou, Bojana Djordjevic, Pamela T Soliman, Qian Zhang, Caimiao Wei, Stephen D Hursting, Karen H Lu, Russell R Broaddus, Cheryl Lyn Walker
发表日期
2016/3/1
期刊
Current molecular medicine
卷号
16
期号
3
页码范围
252-265
出版商
Bentham Science Publishers
简介
Endometrial carcinoma (EC) exhibits the strongest association with obesity of all cancers. Growth of these tumors is driven by PI3K/AKT activation, and opposed by tumor suppressors, including the tuberous sclerosis complex 2 (TSC-2) and p27, with inactivation of TSC2 and loss or cytoplasmic mislocalization of p27 both being linked to PI3K/AKT activation. However, little is known about the involvement of p27 in the development of EC arising in the setting of obesity, especially its role early in disease progression. Using a panel of EC cell lines, in vitro studies using PI3K inhibitors provided evidence that p27 rescue contributes to the efficacy of interventions that inhibit endometrial cell growth. In
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AS McCampbell, ML Mittelstadt, R Dere, S Kim, L Zhou… - Current molecular medicine, 2016