作者
Lijun Zhou, Meilian Liu, Jingjing Zhang, Hongzhi Chen, Lily Q Dong, Feng Liu
发表日期
2010/11/1
期刊
Diabetes
卷号
59
期号
11
页码范围
2809-2816
出版商
American Diabetes Association
简介
OBJECTIVE
Obesity impairs adiponectin expression, assembly, and secretion, yet the underlying mechanisms remain elusive. The aims of this study were 1) to determine the molecular mechanisms by which obesity impairs adiponectin multimerization and stability, and 2) to determine the potential role of disulfide-bond-A oxidoreductase-like protein (DsbA-L), a recently identified adiponectin interactive protein that promotes adiponectin multimerization and stability in obesity-induced endoplasmic reticulum (ER) stress and adiponectin downregulation.
RESEARCH DESIGN AND METHODS
Tauroursodeoxycholic acid (TUDCA), a chemical chaperone that alleviates ER stress, was used to study the mechanism underlying obesity-induced adiponectin downregulation in db/db mice, high-fat diet-induced obese mice, and in ER-stressed 3T3-L1 adipocytes. The cellular levels of DsbA-L …
学术搜索中的文章
L Zhou, M Liu, J Zhang, H Chen, LQ Dong, F Liu - Diabetes, 2010