作者
Tim B Bigdeli, Giulio Genovese, Penelope Georgakopoulos, Jacquelyn L Meyers, Roseann E Peterson, Conrad O Iyegbe, Helena Medeiros, Jorge Valderrama, Eric D Achtyes, Roman Kotov, Eli A Stahl, Colony Abbott, Maria Helena Azevedo, Richard A Belliveau, Elizabeth Bevilacqua, Evelyn J Bromet, William Byerley, Celia Barreto Carvalho, Sinéad B Chapman, Lynn E DeLisi, Ashley L Dumont, Colm O’Dushlaine, Oleg V Evgrafov, Laura J Fochtmann, Diane Gage, James L Kennedy, Becky Kinkead, Antonio Macedo, Jennifer L Moran, Christopher P Morley, Mantosh J Dewan, James Nemesh, Diana O Perkins, Shaun M Purcell, Jeffrey J Rakofsky, Edward M Scolnick, Brooke M Sklar, Pamela Sklar, Jordan W Smoller, Patrick F Sullivan, Fabio Macciardi, Stephen R Marder, Ruben C Gur, Raquel E Gur, David L Braff, Humberto Nicolini, Michael A Escamilla, Marquis P Vawter, Janet L Sobell, Dolores Malaspina, Douglas S Lehrer, Peter F Buckley, Mark H Rapaport, James A Knowles, Genomic Psychiatry Cohort (GPC) Consortium, Ayman H Fanous, Michele T Pato, Steven A McCarroll, Carlos N Pato
发表日期
2020/10
期刊
Molecular Psychiatry
卷号
25
期号
10
页码范围
2455-2467
出版商
Nature Publishing Group UK
简介
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants play a role in the etiology of schizophrenia, most of the currently explained liability is within common variation, suggesting that variation predating the human diaspora out of Africa harbors a large fraction of the common variant attributable heritability. However, common variant association studies in schizophrenia have concentrated mainly on cohorts of European descent. We describe genome-wide association studies of 6152 cases and 3918 controls of admixed African ancestry, and of 1234 cases and 3090 controls of Latino ancestry, representing the largest such study in these populations to date. Combining results from the samples with African ancestry with summary statistics from the Psychiatric Genomics Consortium (PGC) study of schizophrenia …
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TB Bigdeli, G Genovese, P Georgakopoulos, JL Meyers… - Molecular Psychiatry, 2020