作者
Raymond K Walters, Renato Polimanti, Emma C Johnson, Jeanette N McClintick, Mark J Adams, Amy E Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna M Biernacka, Tim B Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Yi-Ling Chou, Franziska Degenhardt, Anna R Docherty, Alexis C Edwards, Pierre Fontanillas, Jerome C Foo, Louis Fox, Josef Frank, Ina Giegling, Scott Gordon, Laura M Hack, Annette M Hartmann, Sarah M Hartz, Stefanie Heilmann-Heimbach, Stefan Herms, Colin Hodgkinson, Per Hoffmann, Jouke Jan Hottenga, Martin A Kennedy, Mervi Alanne-Kinnunen, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Dongbing Lai, Lannie Ligthart, Anu Loukola, Brion S Maher, Hamdi Mbarek, Andrew M McIntosh, Matthew B McQueen, Jacquelyn L Meyers, Yuri Milaneschi, Teemu Palviainen, John F Pearson, Roseann E Peterson, Samuli Ripatti, Euijung Ryu, Nancy L Saccone, Jessica E Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T Webb, Robbee Wedow, Leah Wetherill, Amanda G Wills, Jason D Boardman, Danfeng Chen, Doo-Sup Choi, William E Copeland, Robert C Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W Domingue, Sarah L Elson, Mark A Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison D Murray, John I Nurnberger, Aarno Palotie, Ulrich Preuss, Katri Räikkönen, Maureen D Reynolds, Monika Ridinger, Norbert Scherbaum, Marc A Schuckit, Michael Soyka, Jens Treutlein, Stephanie Witt, Norbert Wodarz, Peter Zill, Daniel E Adkins, Joseph M Boden, Dorret I Boomsma, Laura J Bierut, Sandra A Brown, Kathleen K Bucholz, Sven Cichon, E Jane Costello, Harriet de Wit, Nancy Diazgranados, Danielle M Dick, Johan G Eriksson, Lindsay A Farrer, Tatiana M Foroud, Nathan A Gillespie, Alison M Goate, David Goldman, Richard A Grucza, Dana B Hancock, Kathleen Mullan Harris, Andrew C Heath, Victor Hesselbrock, John K Hewitt, Christian J Hopfer, John Horwood, William Iacono, Eric O Johnson, Jaakko A Kaprio, Victor M Karpyak, Kenneth S Kendler, Henry R Kranzler, Kenneth Krauter, Paul Lichtenstein, Penelope A Lind, Matt McGue, James MacKillop, Pamela AF Madden, Hermine H Maes, Patrik Magnusson, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Elliot C Nelson, Markus M Nöthen, Abraham A Palmer, Nancy L Pedersen, Brenda WJH Penninx, Bernice Porjesz
发表日期
2018/12
期刊
Nature neuroscience
卷号
21
期号
12
页码范围
1656-1669
出版商
Nature Publishing Group US
简介
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case–control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10–13) and African ancestries (rs2066702; P = 2.2 × 10–9). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit–hyperactivity disorder …
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RK Walters, R Polimanti, EC Johnson, JN McClintick… - Nature neuroscience, 2018