作者
Renato Polimanti, Raymond K Walters, Emma C Johnson, Jeanette N McClintick, Amy E Adkins, Daniel E Adkins, Silviu-Alin Bacanu, Laura J Bierut, Tim B Bigdeli, Sandra Brown, Kathleen K Bucholz, William E Copeland, E Jane Costello, Louisa Degenhardt, Lindsay A Farrer, Tatiana M Foroud, Louis Fox, Alison M Goate, Richard Grucza, Laura M Hack, Dana B Hancock, Sarah M Hartz, Andrew C Heath, John K Hewitt, Christian J Hopfer, Eric O Johnson, Kenneth S Kendler, Henry R Kranzler, Kenneth Krauter, Dongbing Lai, Pamela AF Madden, Nicholas G Martin, Hermine H Maes, Elliot C Nelson, Roseann E Peterson, Bernice Porjesz, Brien P Riley, Nancy Saccone, Michael Stallings, Tamara L Wall, Bradley T Webb, Leah Wetherill, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Howard J Edenberg, Arpana Agrawal, Joel Gelernter
发表日期
2020/8
期刊
Molecular Psychiatry
卷号
25
期号
8
页码范围
1673-1687
出版商
Nature Publishing Group UK
简介
To provide insights into the biology of opioid dependence (OD) and opioid use (i.e., exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 opioid-exposed controls, and 32,500 opioid-unexposed controls, including participants of European and African descent (EUR and AFR, respectively). Among the variants identified, rs9291211 was associated with OE (exposed vs. unexposed controls; EUR z = −5.39, p = 7.2 × 10–8). This variant regulates the transcriptomic profiles of SLC30A9 and BEND4 in multiple brain tissues and was previously associated with depression, alcohol consumption, and neuroticism. A phenome-wide scan of rs9291211 in the UK Biobank (N > 360,000) found association of this variant with propensity to use dietary supplements (p = 1.68 × 10–8). With respect to the same OE phenotype in the gene-based analysis, we identified SDCCAG8 (EUR …
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R Polimanti, RK Walters, EC Johnson, JN McClintick… - Molecular psychiatry, 2020