作者
Jonathan RI Coleman, Héléna A Gaspar, Julien Bryois, Enda M Byrne, Andreas J Forstner, Peter A Holmans, Christiaan A de Leeuw, Manuel Mattheisen, Andrew McQuillin, Jennifer M Whitehead Pavlides, Tune H Pers, Stephan Ripke, Eli A Stahl, Stacy Steinberg, Vassily Trubetskoy, Maciej Trzaskowski, Yunpeng Wang, Liam Abbott, Abdel Abdellaoui, Mark J Adams, Annelie Nordin Adolfsson, Esben Agerbo, Huda Akil, Diego Albani, Ney Alliey-Rodriguez, Thomas D Als, Till FM Andlauer, Adebayo Anjorin, Verneri Antilla, Sandra Van der Auwera, Swapnil Awasthi, Silviu-Alin Bacanu, Judith A Badner, Marie Bækvad-Hansen, Jack D Barchas, Nicholas Bass, Michael Bauer, Aartjan TF Beekman, Richard Belliveau, Sarah E Bergen, Tim B Bigdeli, Elisabeth B Binder, Erlend Bøen, Marco Boks, James Boocock, Monika Budde, William Bunney, Margit Burmeister, Henriette N Buttenschøn, Jonas Bybjerg-Grauholm, William Byerley, Na Cai, Miquel Casas, Enrique Castelao, Felecia Cerrato, Pablo Cervantes, Kimberly Chambert, Alexander W Charney, Danfeng Chen, Jane Hvarregaard Christensen, Claire Churchhouse, David St Clair, Toni-Kim Clarke, Lucía Colodro-Conde, William Coryell, Baptiste Couvy-Duchesne, David W Craig, Gregory E Crawford, Cristiana Cruceanu, Piotr M Czerski, Anders M Dale, Gail Davies, Ian J Deary, Franziska Degenhardt, Jurgen Del-Favero, J Raymond DePaulo, Eske M Derks, Nese Direk, Srdjan Djurovic, Amanda L Dobbyn, Conor V Dolan, Ashley Dumont, Erin C Dunn, Thalia C Eley, Torbjørn Elvsåshagen, Valentina Escott-Price, Chun Chieh Fan, Hilary K Finucane, Sascha B Fischer, Matthew Flickinger, Jerome C Foo, Tatiana M Foroud, Liz Forty, Josef Frank, Christine Fraser, Nelson B Freimer, Louise Frisén, Katrin Gade, Diane Gage, Julie Garnham, Claudia Giambartolomei, Fernando S Goes, Jaqueline Goldstein, Scott D Gordon, Katherine Gordon-Smith, Elaine K Green, Melissa J Green, Tiffany A Greenwood, Jakob Grove, Weihua Guan, Lynsey S Hall, Marian L Hamshere, Christine Søholm Hansen, Thomas F Hansen, Martin Hautzinger, Urs Heilbronner, Albert M van Hemert, Stefan Herms, Ian B Hickie, Maria Hipolito, Per Hoffmann, Dominic Holland, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, Laura Huckins, Marcus Ising, Stéphane Jamain, Rick Jansen, Jessica S Johnson, Simone de Jong, Eric Jorgenson, Anders Juréus, Radhika Kandaswamy, Robert Karlsson, James L Kennedy, Farnush Farhadi Hassan Kiadeh, Sarah Kittel-Schneider, James A Knowles, Manolis Kogevinas, Isaac S Kohane, Anna C Koller, Julia Kraft, Warren W Kretzschmar, Jesper Krogh, Ralph Kupka, Zoltán Kutalik, Catharina Lavebratt, Jacob Lawrence, William B Lawson
发表日期
2020/7/15
期刊
Biological psychiatry
卷号
88
期号
2
页码范围
169-184
出版商
Elsevier
简介
Background
Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction.
Methods
To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424).
Results
Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 …
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