作者
Kizzmekia S Corbett, Martha C Nason, Britta Flach, Matthew Gagne, Sarah O’Connell, Timothy S Johnston, Shruti N Shah, Venkata Viswanadh Edara, Katharine Floyd, Lilin Lai, Charlene McDanal, Joseph R Francica, Barbara Flynn, Kai Wu, Angela Choi, Matthew Koch, Olubukola M Abiona, Anne P Werner, Juan I Moliva, Shayne F Andrew, Mitzi M Donaldson, Jonathan Fintzi, Dillon R Flebbe, Evan Lamb, Amy T Noe, Saule T Nurmukhambetova, Samantha J Provost, Anthony Cook, Alan Dodson, Andrew Faudree, Jack Greenhouse, Swagata Kar, Laurent Pessaint, Maciel Porto, Katelyn Steingrebe, Daniel Valentin, Serge Zouantcha, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, Renee van de Wetering, Seyhan Boyoglu-Barnum, Kwanyee Leung, Wei Shi, Eun Sung Yang, Yi Zhang, John-Paul M Todd, Lingshu Wang, Gabriela S Alvarado, Hanne Andersen, Kathryn E Foulds, Darin K Edwards, John R Mascola, Ian N Moore, Mark G Lewis, Andrea Carfi, David Montefiori, Mehul S Suthar, Adrian McDermott, Mario Roederer, Nancy J Sullivan, Daniel C Douek, Barney S Graham, Robert A Seder
发表日期
2021/9/17
期刊
Science
卷号
373
期号
6561
页码范围
eabj0299
出版商
American Association for the Advancement of Science
简介
INTRODUCTION
Mass vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 pandemic. Two mRNA-based vaccines, Moderna’s mRNA-1273 and Pfizer/BioNTech’s BNT162b2, both of which encode the prefusion-stabilized spike glycoprotein S-2P, showed >94% efficacy against symptomatic COVID-19 in interim phase 3 analyses and are currently being administered globally. Several other vaccines have shown 60 to 80% efficacy against symptomatic COVID-19 in phase 3 trials, and a number of candidate vaccines are in earlier stages of clinical development. An immune correlate of protection can be used to inform potential dose reduction, advance approval of other vaccine candidates in lieu of phase 3 efficacy data, extend indications for use to other age groups, and provide insights into the immune …
学术搜索中的文章
KS Corbett, MC Nason, B Flach, M Gagne, S O'Connell… - Science, 2021