作者
Matthew Gagne, Juan I Moliva, Kathryn E Foulds, Shayne F Andrew, Barbara J Flynn, Anne P Werner, Danielle A Wagner, I-Ting Teng, Bob C Lin, Christopher Moore, Nazaire Jean-Baptiste, Robin Carroll, Stephanie L Foster, Mit Patel, Madison Ellis, Venkata-Viswanadh Edara, Nahara Vargas Maldonado, Mahnaz Minai, Lauren McCormick, Christopher Cole Honeycutt, Bianca M Nagata, Kevin W Bock, Caitlyn NM Dulan, Jamilet Cordon, Dillon R Flebbe, John-Paul M Todd, Elizabeth McCarthy, Laurent Pessaint, Alex Van Ry, Brandon Narvaez, Daniel Valentin, Anthony Cook, Alan Dodson, Katelyn Steingrebe, Saule T Nurmukhambetova, Sucheta Godbole, Amy R Henry, Farida Laboune, Jesmine Roberts-Torres, Cynthia G Lorang, Shivani Amin, Jessica Trost, Mursal Naisan, Manjula Basappa, Jacquelyn Willis, Lingshu Wang, Wei Shi, Nicole A Doria-Rose, Yi Zhang, Eun Sung Yang, Kwanyee Leung, Sijy O’Dell, Stephen D Schmidt, Adam S Olia, Cuiping Liu, Darcy R Harris, Gwo-Yu Chuang, Guillaume Stewart-Jones, Isabella Renzi, Yen-Ting Lai, Agata Malinowski, Kai Wu, John R Mascola, Andrea Carfi, Peter D Kwong, Darin K Edwards, Mark G Lewis, Hanne Andersen, Kizzmekia S Corbett, Martha C Nason, Adrian B McDermott, Mehul S Suthar, Ian N Moore, Mario Roederer, Nancy J Sullivan, Daniel C Douek, Robert A Seder
发表日期
2022/4/28
期刊
Cell
卷号
185
期号
9
页码范围
1556-1571. e18
出版商
Elsevier
简介
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were 4,760 and 270 reciprocal ID50 at week 6 (peak) and week 41 (preboost), respectively, and 320 and 110 for Omicron. 2 weeks after the boost, titers against D614G and Omicron increased to 5,360 and 2,980 for mRNA-1273 boost and 2,670 and 1,930 for mRNA-Omicron, respectively. Similar increases against BA.2 were observed. Following either boost, 70%–80% of spike-specific B cells were cross-reactive against WA1 and Omicron. Equivalent control of virus replication in lower airways was …
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