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The International Network for the Demographic Evaluation of Populations and their Health (INDEPTH) Network is an umbrella organization for a group of independent health research centres operating health and demographic surveillance system (HDSS) sites in low-and middle-income countries (LMICs). Founded in 1998, it brought together a number of existing HDSS sites, and since then has encouraged newer HDSS sites to join. 1 The purpose of this Editorial is to set the scene for a series of profiles from INDEPTH HDSS member sites, the first examples of which are published in this edition of IJE. 2–5 All these profiles will follow a set pattern, to facilitate a systematic understanding of the multiplicity of HDSS sites involved in the Network and the various ways in which they are operated by their parent institutions. This Editorial therefore, follows the same general pattern as the individual profiles, but seeks to …