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In this paper, we provide a new approach to solve approximately a system of fractional differential equations (FDEs). We extend this approach for approximately solving a fractional-order differential equation model of HIV infection of CD4+T cells with therapy effect. The fractional derivative in our approach is in the sense of Riemann-Liouville. To solve the problem, we reduce the system of FDE to a discrete optimization problem. By obtaining the optimal solutions of new problem by minimization the total errors, we obtain the approximate solution of the original problem. The numerical solutions obtained from the proposed approach indicate that our approximation is easy to implement and accurate when it is applied to a systems of FDEs.