作者
Gábor Kemenesi, Gábor E Tóth, Martin Mayora-Neto, Simon Scott, Nigel Temperton, Edward Wright, Elke Mühlberger, Adam J Hume, Ellen L Suder, Brigitta Zana, Sándor A Boldogh, Tamás Görföl, Péter Estók, Tamara Szentiványi, Zsófia Lanszki, Balázs A Somogyi, Ágnes Nagy, Csaba I Pereszlényi, Gábor Dudás, Fanni Földes, Kornélia Kurucz, Mónika Madai, Safia Zeghbib, Piet Maes, Bert Vanmechelen, Ferenc Jakab
发表日期
2022/3/31
期刊
nature communications
卷号
13
期号
1
页码范围
1706
出版商
Nature Publishing Group UK
简介
Some filoviruses can be transmitted to humans by zoonotic spillover events from their natural host and filovirus outbreaks have occured with increasing frequency in the last years. The filovirus Lloviu virus (LLOV), was identified in 2002 in Schreiber’s bats (Miniopterus schreibersii) in Spain and was subsequently detected in bats in Hungary. Here we isolate infectious LLOV from the blood of a live sampled Schreiber’s bat in Hungary. The isolate is subsequently sequenced and cultured in the Miniopterus sp. kidney cell line SuBK12-08. It is furthermore able to infect monkey and human cells, suggesting that LLOV might have spillover potential. A multi-year surveillance of LLOV in bats in Hungary detects LLOV RNA in both deceased and live animals as well as in coupled ectoparasites from the families Nycteribiidae and Ixodidae. This correlates with LLOV seropositivity in sampled Schreiber’s bats. Our data support …
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G Kemenesi, GE Tóth, M Mayora-Neto, S Scott… - nature communications, 2022