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This report summarizes the efforts and results of the research project “Large Truck Crash Analysis for Freight Mobility and Safety Enhancement in Florida”, which was intended to gain more understanding of the patterns and contributing factors of large truck crashes in Florida, to recommend practical countermeasures to reduce crashes involving freight, and to enhance freight mobility and safety. A comprehensive statewide crash analysis was conducted focusing on large truck-involved crashes in the past ten years, between 2007 and 2016. Three different approaches were undertaken to analyze the crash data. A framework was developed to identify the critical reason for individual crashes, which provided insights into the potential causes or factors that lead to increasing risk of a crash. Disaggregate crash severity analysis was conducted to investigate the impacts of contributing factors on crash severity outcomes through random parameter ordered logit (RPOL) models. Spatial analysis was also conducted to illustrate the spatial pattern of large truck crashes and identify concentration or problematics areas, using an ArcGIS Spatial Analyst extension, the Kernel Density tool. Incorporating findings from the three major crash analysis efforts, a data-driven and evidence-based set of countermeasures was developed that target the behavioral factors and critical locations identified from those efforts. A group of selected systemic countermeasures were presented and discussed with some examples representing the common applications. Targeted countermeasures were then recommended for 35 priority locations identified in the state of Florida …