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Plant-based procedures continue to play an vital role in health protection, and their use by individual civilization has been astronomically reported. The plants of the Arecaceae family composed of about 181 genera and 2600 species mainly distributed in tropical and sub tropical ecological zones as well as in the Arabian deserts and throughout the continents of Africa, Latin America, South and South-East Asia and has been habitually used for treatment of several diseases. The present study aimed to provide a general review of the available literature on ethanomedical, phytoconstituents, and biological data related to the Family Arecaceae as a potential source of new compounds with therapeutic applications. Considering Traditional uses, in the treatment of various gastrointestinal diseases, killing parasites, curing kidney asthenia, tinnitus, diarrhea treatment, amenorrhea, venereal diseases etc. phytochemical studies, flavonoids, fatty acids, carotenoids, spirostan, terpenes, amino acids, tannins, alkaloids and phenolic acids were the main classes of compounds identified in roots, leaf, fruit and seeds which were correlated with their biological activities as anti-microbial, anti-fungal, anti-parasitic, anti-allergic, antidiabetic, antineoplastic, anti-inflammatory or antioxidant agents.