作者
Ariane Fillmer, Andreas Hock, Donnie Cameron, Anke Henning
发表日期
2017/12/4
期刊
Scientific reports
卷号
7
期号
1
页码范围
16898
出版商
Nature Publishing Group UK
简介
Conditions such as type II diabetes are linked with elevated lipid levels in the heart, and significantly increased risk of heart failure; however, metabolic processes underlying the development of cardiac disease in type II diabetes are not fully understood. Here we present a non-invasive method for in vivo investigation of cardiac lipid metabolism: namely, IVS-McPRESS. This technique uses metabolite-cycled, non-water suppressed 1H cardiac magnetic resonance spectroscopy with prospective and retrospective motion correction. High-quality IVS-McPRESS data acquired from healthy volunteers allowed us to investigate the frequency shift of extramyocellular lipid signals, which depends on the myocardial fibre orientation. Assuming consistent voxel positioning relative to myofibres, the myofibre angle with the magnetic field was derived from the voxel orientation. For separation and individual analysis of intra- and …
学术搜索中的文章
A Fillmer, A Hock, D Cameron, A Henning - Scientific reports, 2017