作者
Jan M Dieleman, Arno P Nierich, Peter M Rosseel, Joost M van der Maaten, Jan Hofland, Jan C Diephuis, Ronald M Schepp, Christa Boer, Karel G Moons, Lex A van Herwerden, Jan G Tijssen, Sandra C Numan, Cor J Kalkman, Diederik van Dijk, Dexamethasone for Cardiac Surgery (DECS) Study Group
发表日期
2012/11/7
期刊
Jama
卷号
308
期号
17
页码范围
1761-1767
出版商
American Medical Association
简介
Context
Prophylactic corticosteroids are often administered during cardiac surgery to attenuate the inflammatory response to cardiopulmonary bypass and surgical trauma; however, evidence that routine corticosteroid use can prevent major adverse events is lacking.
Objective
To quantify the effect of intraoperative high-dose dexamethasone on the incidence of major adverse events in patients undergoing cardiac surgery.
Design, Setting, and Participants
A multicenter, randomized, double-blind, placebo-controlled trial of 4494 patients aged 18 years or older undergoing cardiac surgery with cardiopulmonary bypass at 8 cardiac surgical centers in the Netherlands enrolled between April 13, 2006, and November 23, 2011.
Intervention
Patients were randomly assigned to receive a single intraoperative dose of 1 mg/kg dexamethasone (n = 2239) or placebo (n = 2255).
Main Outcome Measures
A composite of death …
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