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The outbreak of Covid-19 created disruptions in manufacturing operations. One of the most serious negative impacts is the shortage of critical medical supplies. Manufacturing firms faced pressure from governments to use their manufacturing capacity to repurpose their production for meeting the critical demand for necessary products. For this purpose, recent advancements in technology and artificial intelligence (AI) could act as response solutions to conquer the threats linked with repurposing manufacturing (RM). The study’s purpose is to investigate the significance of AI in RM through a systematic literature review (SLR). This study gathered around 453 articles from the SCOPUS database in the selected research field. Structural Topic Modelling (STM) was utilised to generate emerging research themes from the selected documents on AI in RM. In addition, to study the research trends in the field of AI in RM, a …