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Over the past decade, there has been a constant spotlight on introducing sustainability in the supply chain (SC). The materialistic human greed for production and consumption has led to a radically increased level of greenhouse gases. SC has become its principal contributor. We are addressing this socio-economic environmental challenge by developing a multi-stakeholder framework and focusing on a knowledge-based net zero supply chain, as there are no concrete existing studies that have investigated current state-of-the-art operations in this relevant field. Therefore, this research has been conducted to investigate the drivers, barriers and practices through which net zero economy (NZE) can be attained in a knowledge-based SC. In this regard, the paper conducts an exploratory systematic review of selected articles from peer-reviewed journals. The findings indicate that primary stakeholders (i.e …