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This study developed and characterized the chitosan-functionalized Fe₃O₄@SiO₂ nanoparticles (Fe₃O₄@SiO₂@CS NP) as a drug delivery system. Fe₃O₄ NP were first synthesized by co-precipitation method, followed by coating with SiO₂, and functionalized with chitosan via glutaraldehyde crosslinking bridges. The newly synthesized Fe₃O₄@SiO₂@CS NP possessed an octagonal shape with a diameter of ~ 20 nm. In the FT-IR spectrum, the Fe₃O₄@SiO₂@CS NP demonstrated the appearances of C–O, N–H, and C–H peaks, indicating the presence of chitosan in their structures. The Fe₃O₄@SiO₂@CS NP could preserve the Fe₃O₄ magnetic property with a magnetization value of 52.43 emu/g, a magnetization remanence of almost 0 emu/g, and minimal residual coercivity. Utilizing curcumin as a drug model, the Fe₃O₄@SiO₂@CS NP could adsorb the drug rapidly, to more than 71% within 20 min, with an …