查看文章

Dermatophytes, a group of fungal species causing superficial fungal infections possess a major health problem in a wide group of people. Various approaches have been used in past for treatment of such infections but, owning to their low dermal permeability and less retention time, such formulations are proven to be less effective. Thus, to overcome such limitations, various novel drug delivery systems were developed. “Nanosponge” - a porous nano carrier system which can entrap drug of choice and improve its dermal availability, permeation rate and retention time is one such example. In the present study, a novel azole antifungal drug luliconazole, having wide spectrum of activity and potent against dermatophytes was used as model drug. It has low aqueous solubility and less dermal availability. A regular 2-level factorial design was applied using Design Expert® 11 software to formulate luliconazole loaded …