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Mucoadhesive buccal patches containing propranolol hydrochloride were prepared using solvent casting method was develop and evaluate for in-vitro performance using hydrophobic polymer eudragit L-100. In preparation of patches hydrophilic polymers like carbopol-934 and PVP K-30 were incorporated to modify bioadhesive properties, and drug release rate. Patches were evaluated for surface pH, folding endurance, swelling index, ex-vivo mucoadhesive strength, in-vitro drug release and in-vitro buccal permeation. The prepared patches were smooth, elegant in appearance, uniform in thickness, weight, and drug content and showed no visible cracks and showing good folding endurance. Results indicates that the high amount of carbopol 934 and low amount of PVP K30 favor the ex-vivo mucoadhesive strength of the patches but low amount of carbopol 934 and high amount of PVP K30 favor the dissolution rate (t50, t80) and swelling index of the patches. It can be concluded from present study that mucoadhesive patches of eudragit could be a useful carrier in buccal drug delivery systems.