作者
Yesim Dargaud, Suzette Béguin, Anne Lienhart, Raed Al Dieri, Christine Trzeciak, Jean Claude Bordet, Coenraad H Hemker, Claude Negrier
发表日期
2005
期刊
Thrombosis and haemostasis
卷号
93
期号
03
页码范围
475-480
出版商
Schattauer GmbH
简介
In haemophilia patients, a relationship is usually observed between the clinical expression of the disease and plasmatic factor VIII/factor IX (FVIII/FIX) activity. However, it is known from clinical experience, that some haemophilia patients, despite similar FVIII/FIX plasma levels, could exhibit different bleeding phenotype. After determining preanalytical test conditions, we evaluated the thrombin generation capacity from haemophilia plasma samples in various conditions and the potential usefulness of thrombin generation test (TGT) in haemophilia patients. In a series of 46 haemophilia patients (34 haemophilia A and 12 haemophilia B patients), we found a significant correlation between plasmatic FVIII/FIX levels and endogenous thrombin potential (ETP), peak and time to peak obtained by thrombin generation measurement. In addition, a correlation was found between severe clinical bleeding phenotype and ETP …
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Y Dargaud, S Béguin, A Lienhart, R Al Dieri, C Trzeciak… - Thrombosis and haemostasis, 2005