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This paper presents algorithms based on differential evolution (DE) to solve the generalized assignment problem (GAP) with the objective to minimize the assignment cost under the limitation of the agent capacity. Three local search techniques: shifting, exchange, and k-variable move algorithms are added to the DE algorithm in order to improve the solutions. Eight DE-based algorithms are presented, each of which uses DE with a different combination of local search techniques. The experiments are carried out using published standard instances from the literature. The best proposed algorithm using shifting and k-variable move as the local search (DE-SK) techniques was used to compare its performance with those of Bee algorithm (BEE) and Tabu search algorithm (TABU). The computational results revealed that the BEE and DE-SK are not significantly different while the DE-SK outperforms the TABU algorithm …