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Machine learning is a subset of Artificial Intelligence when combined with Data Mining techniques plays a promising role in the field of prediction. We live in an era where data generation is exponential with time but if the generated data is not put to work or not converted to knowledge data, its generation is of no use. Similarly, in Healthcare also, data availability is high, so is the need to extract the information from it for better prognosis, diagnosis, treatment, drug development, and overall healthcare. In this research, we have tried to focus more on diagnosis of Diabetes disease, which is one of the fastest growing chronic diseases all over the world as declared by World Health Organization in the year 2014. We have also tried to show the different techniques like Gradient Boosting, Logistic Regression and Naive Bayes, which can be used for the diagnosis of diabetes disease with attained accuracy as 86 …