作者
Pablo Lindner, Sushmita Paul, Markus Eckstein, Chuanpit Hampel, Julienne K Muenzner, Katharina Erlenbach-Wuensch, Husayn P Ahmed, Vijayalakshmi Mahadevan, Thomas Brabletz, Arndt Hartmann, Julio Vera, Regine Schneider-Stock
发表日期
2020/2/24
期刊
Cell death & disease
卷号
11
期号
2
页码范围
147
出版商
Nature Publishing Group UK
简介
Epigenetic deregulation remarkably triggers mechanisms associated with tumor aggressiveness like epithelial–mesenchymal transition (EMT). Since EMT is a highly complex, but also reversible event, epigenetic processes such as DNA methylation or chromatin alterations must be involved in its regulation. It was recently described that loss of the cell cycle regulator p21 was associated with a gain in EMT characteristics and an upregulation of the master EMT transcription factor ZEB1. In this study, in silico analysis was performed in combination with different in vitro and in vivo techniques to identify and verify novel epigenetic targets of ZEB1, and to proof the direct transcriptional regulation of SETD1B by ZEB1. The chorioallantoic-membrane assay served as an in vivo model to analyze the ZEB1/SETD1B interaction. Bioinformatical analysis of CRC patient data was used to examine the ZEB1/SETD1B network under …
学术搜索中的文章
P Lindner, S Paul, M Eckstein, C Hampel, JK Muenzner… - Cell death & disease, 2020