查看文章

To study the effects of atrazine on reproductive functions and testicular and epididymal antioxidant defense, rats were exposed to 0, 120, or 200 mg/kg body weight atrazine orally for 7 and 16 days. Animals exposed to the high-dose atrazine had their body weights, feed intake, and reproductive organs weights significantly reduced, whereas testicular weights remain unaffected independent of the dose used. In comparison to control, glutathione (GSH) and glutathione-S-transferase (GST) activities were elevated in the high-dose group, whereas the activity of superoxide dismutase (SOD), catalase (CAT); ascorbate (AA), and malondialdehyde (MDA) levels and hydrogen peroxide production were unchanged in the testis during the 7-day-exposure protocol. When atrazine treatment was increased to 16 days, GSH levels remained unchanged, but lipid peroxidation levels were significantly increased in both the …