作者
Jiadai Wu, Anthony L Cunningham, Fariba Dehghani, Russell J Diefenbach
发表日期
2016/9/1
期刊
Gene Reports
卷号
4
页码范围
123-130
出版商
Elsevier
简介
We have obtained for the first time the complete cDNA sequences encoding the two known hemocyanin isoforms from the mollusc Haliotis rubra. Based on the predicted amino acid sequence each isoform has an almost identical estimated molecular mass of ~ 390 kDa. The isoforms share an amino acid sequence similarity of 66% and consist of eight functional units (FUs a–h) separated by variable linker regions. As observed in other molluscan hemocyanins, FU-h has a C-terminal extension of ~ 100 amino acids. The presence of a conserved di-copper binding domain in each FU, which contributes to hemocyanin's role as an oxygen transporter, was also confirmed. The most closely related sequences to H. rubra were those of the hemocyanin isoforms from Haliotis tuberculata with a homology of > 90%. Like the hemocyanin isoforms from H. tuberculata, the H. rubra versions contain several predicted N-linked …
学术搜索中的文章
J Wu, AL Cunningham, F Dehghani, RJ Diefenbach - Gene Reports, 2016