作者
Andrea Danese, Terrie E Moffitt, HonaLee Harrington, Barry J Milne, Guilherme Polanczyk, Carmine M Pariante, Richie Poulton, Avshalom Caspi
发表日期
2009/12/7
期刊
Archives of pediatrics & adolescent medicine
卷号
163
期号
12
页码范围
1135-1143
出版商
American Medical Association
简介
Objective
To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether adverse childhood experiences predict enduring abnormalities in stress-sensitive biological systems, namely, the nervous, immune, and endocrine/metabolic systems.
Design
A 32-year prospective longitudinal study of a representative birth cohort.
Setting
New Zealand.
Participants
A total of 1037 members of the Dunedin Multidisciplinary Health and Development Study.
Main Exposures
During their first decade of life, study members were assessed for exposure to 3 adverse psychosocial experiences: socioeconomic disadvantage, maltreatment, and social isolation.
Main Outcome Measures
At age 32 years, study members were assessed for the presence of 3 age-related-disease risks: major depression, high inflammation levels (high …
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