作者
Dami A Collier, Anna De Marco, Isabella ATM Ferreira, Bo Meng, Rawlings P Datir, Alexandra C Walls, Steven A Kemp, Jessica Bassi, Dora Pinto, Chiara Silacci-Fregni, Siro Bianchi, M Alejandra Tortorici, John Bowen, Katja Culap, Stefano Jaconi, Elisabetta Cameroni, Gyorgy Snell, Matteo S Pizzuto, Alessandra Franzetti Pellanda, Christian Garzoni, Agostino Riva, Clinical data collection De Bie Eckart MDD 3 Bunclark Katherine 3 Josipovic Masa 33 Mackay Michael 3 Rossi Sabrina 34 Selvan Mayurun 3 Spencer Sarah 35 Yong Cissy 34, Royal Papworth Hospital ICU Ansaripour Ali 23 Michael Alice 23 Mwaura Lucy 23 Patterson Caroline 23 Polwarth Gary 23, Addenbrooke’s Hospital ICU Polgarova Petra 24 di Stefano Giovanni 24, Cambridge & Peterborough Foundation Trust Fahey Codie 36 Michel Rachel 36, ANPC & Centre for Molecular Medicine & Innovative Therapeutics Bong Sze-How 37 Coudert Jerome D. 38 Holmes Elaine 39, Funding acquisition, leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis, software & analysis tools and visualization Robson Samuel C. 32, Funding acquisition, leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis and software & analysis tools Loman Nicholas J. 33 Connor Thomas R. 26 41, Leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis, software & analysis tools and visualization Golubchik Tanya 42, Funding acquisition, metadata curation, samples & logistics, sequencing & analysis, software & analysis tools and visualization Martinez Nunez Rocio T. 43, Funding acquisition, leadership & supervision, metadata curation, project administration and samples & logistics Ludden Catherine 2, Funding acquisition, leadership & supervision, metadata curation, samples & logistics and sequencing & analysis Corden Sally 41, Funding acquisition, leadership & supervision, project administration, samples & logistics and sequencing & analysis Johnston Ian 44 Bonsall David 42, Funding acquisition, leadership & supervision, sequencing & analysis, software & analysis tools and visualization Smith Colin P. 45 Awan Ali R. 46, Funding acquisition, samples & logistics, sequencing & analysis, software & analysis tools and visualization Bucca Giselda 45, Leadership & supervision, metadata curation, project administration, samples & logistics and sequencing & analysis Torok M. Estee 3 47 48, Leadership & supervision, metadata curation, project administration, samples & logistics and visualization Saeed Kordo 49 50 Prieto Jacqui A. 49 51, Leadership & supervision, metadata curation, project administration, sequencing & analysis and software & analysis tools Jackson David K. 44, Metadata curation, project administration, samples & logistics, sequencing & analysis and software & analysis tools Hamilton William L. 47 48, Metadata curation, project administration, samples & logistics, sequencing & analysis and visualization Snell Luke B. 52, Funding acquisition, leadership & supervision, metadata curation and samples & logistics Moore Catherine 41, Funding acquisition, leadership & supervision, project administration and samples & logistics Harrison Ewan M. 2 44, Leadership & supervision, metadata curation, project administration and samples & logistics Goncalves Sonia 44, Leadership & supervision, metadata curation, samples & logistics and sequencing & analysis Fairley Derek J. 53 54 Loose Matthew W. 55 Watkins Joanne 41, Leadership & supervision, metadata curation, samples & logistics and software & analysis tools Livett Rich 44, Leadership & supervision, metadata curation, samples & logistics and visualization Moses Samuel 56 57, Leadership & supervision, metadata curation, sequencing & analysis and software & analysis tools Amato Roberto 44 Nicholls Sam 33 Bull Matthew 41, Leadership & supervision, project administration, samples & logistics and sequencing & analysis Smith Darren L. 58 59 60, Leadership & supervision, sequencing & analysis, software & analysis tools and visualization Barrett Jeff 44 Aanensen David M. 61, Metadata curation, project administration, samples & logistics and sequencing & analysis Curran Martin D. 62 Parmar Surendra 62 Aggarwal Dinesh 2 44 63 Shepherd James G. 64, Metadata curation, project administration, sequencing & analysis and software & analysis tools Parker Matthew D. 65, Metadata curation, samples & logistics, sequencing & analysis and visualization Glaysher Sharon 66, Metadata curation, sequencing & analysis, software & analysis tools and visualization Bashton Matthew 58 59 Underwood Anthony P. 61 Pacchiarini Nicole 41 Loveson Katie F. 67, Project administration, sequencing & analysis, software & analysis tools and visualization Carabelli Alessandro M. 2, Funding acquisition, leadership & supervision and metadata curation Templeton Kate E. 68 69, Funding acquisition, leadership & supervision and project administration Langford Cordelia F. 44 Sillitoe John 44 de Silva Thushan I. 65 Wang Dennis 65, Funding acquisition, leadership & supervision and sequencing & analysis Kwiatkowski Dominic 44 70 Rambaut Andrew 69 O’Grady Justin 71 72 Cottrell Simon 41, Leadership & supervision, metadata curation and sequencing & analysis Holden Matthew TG 73 Thomson Emma C. 64, Leadership & supervision, project administration and samples & logistics Osman Husam 63 74 Andersson Monique 75 Chauhan Anoop J. 66 Hassan-Ibrahim Mohammed O. 76, Leadership & supervision, project administration and sequencing & analysis Lawniczak Mara 44, Leadership & supervision, samples & logistics and sequencing & analysis Alderton Alex 44 Chand Meera 63 Constantinidou Chrystala 77 Unnikrishnan Meera 77 Darby Alistair C. 78 Hiscox Julian A. 78 Paterson Steve 78, Leadership & supervision, sequencing & analysis and software & analysis tools Martincorena Inigo 44 Robertson David L. 64 Volz Erik M. 79 Page Andrew J. 71 Pybus Oliver G. 80, Leadership & supervision, sequencing & analysis and visualization Bassett Andrew R. 44, Metadata curation, project administration and samples & logistics Ariani Cristina V. 44 Spencer Chapman Michael H. 2 44 Li Kathy K. 64 Shah Rajiv N. 64 Jesudason Natasha G. 64 Taha Yusri 81, Metadata curation, project administration and sequencing & analysis McHugh Martin P. 68 Dewar Rebecca 68, Metadata curation, samples & logistics and sequencing & analysis Jahun Aminu S. 82 McMurray Claire 33 Pandey Sarojini 83 McKenna James P. 53 Nelson Andrew 59 60 Young Gregory R. 58 59 McCann Clare M. 59 60 Elliott Scott 66, Metadata curation, samples & logistics and visualization Lowe Hannah 56, Metadata curation, sequencing & analysis and software & analysis tools Temperton Ben 84 Roy Sunando 85 Price Anna 26 Rey Sara 41 Wyles Matthew 65, Metadata curation, sequencing & analysis and visualization Rooke Stefan 69 Shaaban Sharif 73, Project administration, samples & logistics and sequencing & analysis de Cesare Mariateresa 86, Project administration, samples & logistics and software & analysis tools Letchford Laura 44, Project administration, samples & logistics and visualization Silveira Siona 49 Pelosi Emanuela 49 Wilson-Davies Eleri 49, Samples & logistics, sequencing & analysis and software & analysis tools Hosmillo Myra 82, Sequencing & analysis, software & analysis tools and visualization O’Toole Áine 69 Hesketh Andrew R. 45 Stark Richard 77 du Plessis Louis 80 Ruis Chris 2 Adams Helen 87 Bourgeois Yann 88, Funding acquisition & leadership and supervision Michell Stephen L. 84 Grammatopoulos Dimitris 83 89 Edgeworth Jonathan 90 Breuer Judith 85 91 Todd John A. 86 Fraser Christophe 42, Funding acquisition and project administration Buck David 86 John Michaela 92, Leadership & supervision and metadata curation Kay Gemma L. 71, Leadership & supervision and project administration Palmer Steve 44 Peacock Sharon J. 2 63 Heyburn David 41, Leadership & supervision and samples & logistics Weldon Danni 44 Robinson Esther 63 74 McNally Alan 33 93 Muir Peter 63 Vipond Ian B. 63 Boyes John 94 Sivaprakasam Venkat 95 Salluja Tranprit 96 Dervisevic Samir 97 Meader Emma J. 97, Leadership & supervision and sequencing & analysis Park Naomi R. 44 Oliver Karen 44 Jeffries Aaron R. 84 Ott Sascha 77 da Silva Filipe Ana 64 Simpson David A. 54 Williams Chris 41, Leadership & supervision and visualization Masoli Jane AH 84 98, Metadata curation and software & analysis tools Davies Robert 44, Project administration and sequencing & analysis Hadjirin Nazreen F. 2 Quick Joshua 33, Project administration and software & analysis tools Poplawski Radoslaw 33, Samples & logistics and software & analysis tools Starinskij Igor 64, Software & analysis tools and visualization Keatley Jon-Paul 44 Singer Joshua B. 64 de Oliveira Martins Leonardo 71 Yeats Corin A. 61 Abudahab Khalil 61 Taylor Ben EW 61 Menegazzo Mirko 61, Software & analysis tools Bonfield James 44 Puethe Christoph 44 Whitwham Andrew 44 Liddle Jennifier 44 Rowe Will 33 Siveroni Igor 79 Le-Viet Thanh 71 Gaskin Amy 41, Visualization Johnson Rob 79
发表日期
2021/5/6
期刊
Nature
卷号
593
期号
7857
页码范围
136-141
出版商
Nature Publishing Group UK
简介
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant, which has now been reported in 94 countries. It is unclear whether the response of the virus to vaccines against SARS-CoV-2 on the basis of the prototypic strain will be affected by the mutations found in B.1.1.7. Here we assess the immune responses of individuals after vaccination with the mRNA-based vaccine BNT162b2. We measured neutralizing antibody responses after the first and second immunizations using pseudoviruses that expressed the wild-type spike protein or a mutated spike protein that contained the eight amino acid changes found in the B.1.1.7 variant. The sera from individuals who received the vaccine exhibited a broad range of neutralizing titres against the wild-type pseudoviruses that were modestly reduced against the B.1 …
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DA Collier, A De Marco, IATM Ferreira, B Meng… - Nature, 2021