作者
Tinca JC Polderman, Beben Benyamin, Christiaan A De Leeuw, Patrick F Sullivan, Arjen Van Bochoven, Peter M Visscher, Danielle Posthuma
发表日期
2015/7
期刊
Nature genetics
卷号
47
期号
7
页码范围
702-709
出版商
Nature Publishing Group
简介
Despite a century of research on complex traits in humans, the relative importance and specific nature of the influences of genes and environment on human traits remain controversial. We report a meta-analysis of twin correlations and reported variance components for 17,804 traits from 2,748 publications including 14,558,903 partly dependent twin pairs, virtually all published twin studies of complex traits. Estimates of heritability cluster strongly within functional domains, and across all traits the reported heritability is 49%. For a majority (69%) of traits, the observed twin correlations are consistent with a simple and parsimonious model where twin resemblance is solely due to additive genetic variation. The data are inconsistent with substantial influences from shared environment or non-additive genetic variation. This study provides the most comprehensive analysis of the causes of individual differences in human …
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