作者
International Schizophrenia Consortium Manuscript preparation Purcell Shaun M. shaun@ pngu. mgh. harvard. edu 1 2 b Wray Naomi R. 5 Stone Jennifer L. 1 2 3 4 Visscher Peter M. 5 O'Donovan Michael C. 6 Sullivan Patrick F. 7 Sklar Pamela 1 2 3 4, Polygene analyses subgroup Wray Naomi R. 5 Macgregor Stuart 5 Sklar Pamela sklar@ chgr. mgh. harvard. edu 1 2 3 4 d Sullivan Patrick F. 7 O’Donovan Michael C. 6 Visscher Peter M. 5, Hugh Gurling, Douglas HR Blackwood, Aiden Corvin, Nick J Craddock, Michael Gill, Christina M Hultman, George K Kirov, Paul Lichtenstein, Andrew McQuillin, Walter J Muir, Michael C O'Donovan, Michael J Owen, Carlos N Pato, Shaun M Purcell, Edward M Scolnick, David St Clair, Jennifer L Stone, Patrick F Sullivan, Pamela Sklar, Michael C O'Donovan, George K Kirov, Nick J Craddock, Peter A Holmans, Nigel M Williams, Lyudmila Georgieva, Ivan Nikolov, Nadine Norton, H Williams, Draga Toncheva, Vihra Milanova, Michael J Owen, Christina M Hultman, Paul Lichtenstein, Emma F Thelander, Patrick Sullivan, Derek W Morris, Colm T O'Dushlaine, Elaine Kenny, Emma M Quinn, Michael Gill, Aiden Corvin, Andrew McQuillin, Khalid Choudhury, Susmita Datta, Jonathan Pimm, Srinivasa Thirumalai, Vinay Puri, Robert Krasucki, Jacob Lawrence, Digby Quested, Nicholas Bass, Hugh Gurling, Caroline Crombie, Gillian Fraser, Soh Leh Kuan, Nicholas Walker, David St Clair, Douglas HR Blackwood, Walter J Muir, Kevin A McGhee, Ben Pickard, Pat Malloy, Alan W Maclean, Margaret Van Beck, Naomi R Wray, Stuart Macgregor, Peter M Visscher, Michele T Pato, Helena Medeiros, Frank Middleton, Celia Carvalho, Christopher Morley, Ayman Fanous, David Conti, James A Knowles, Carlos Paz Ferreira, Antonio Macedo, M Helena Azevedo, Carlos N Pato, Jennifer L Stone, Douglas M Ruderfer, Andrew N Kirby, Manuel AR Ferreira, Mark J Daly, Shaun M Purcell, Pamela Sklar, Shaun M Purcell, Jennifer L Stone, Kimberly Chambert, Douglas M Ruderfer, Finny Kuruvilla, Stacey B Gabriel, Kristin Ardlie, Jennifer L Moran, Mark J Daly, Edward M Scolnick, Pamela Sklar
发表日期
2009/8/6
期刊
Nature
卷号
460
期号
7256
页码范围
748-752
出版商
Nature Publishing Group UK
简介
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%,. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
引用总数
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