作者
Dalia Elebeedy, Aml Ghanem, Shaza H Aly, Mohamed A Ali, Ahmed HI Faraag, Mohamed K El-Ashrey, Aya M Salem, Mahmoud A El Hassab, Ahmed I Abd El Maksoud
发表日期
2023/6/30
期刊
BMC microbiology
卷号
23
期号
1
页码范围
173
出版商
BioMed Central
简介
Background
The emergence of different viral infections calls for the development of new, effective, and safe antiviral drugs. Glycyrrhiza glabra is a well-known herbal remedy possessing antiviral properties.
Objective
The objective of our research was to evaluate the effectiveness of a newly developed combination of the probiotics Lactobacillus acidophilus and G. glabra root extract against two viral models, namely the DNA virus Herpes simplex virus-1 (HSV-1) and the RNA virus Vesicular Stomatitis Virus (VSV), with regards to their antiviral properties.
Methodology
To examine the antiviral impacts of various treatments, we employed the MTT assay and real-time PCR methodology.
Results
The findings of our study indicate that the co-administration of L. acidophilus and G. glabra resulted in a significant improvement in the survival rate of Vero cells, while also leading to a reduction in the titers of Herpes Simplex Virus …
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