作者
Abolfazl Torabi, Esmaeil Mohammadbagheri, Nader Akbari Dilmaghani, Amir-Hossein Bayat, Mobina Fathi, Kimia Vakili, Rafieh Alizadeh, Omidvar Rezaeimirghaed, Mohammadreza Hajiesmaeili, Mahtab Ramezani, Leila Simani, Abbas Aliaghaei
发表日期
2020/6/11
期刊
ACS chemical neuroscience
卷号
11
期号
13
页码范围
1909-1913
出版商
American Chemical Society
简介
Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and interleukin-1-beta (IL-1β) were assessed using ELISA and compared between groups. Average TNF-α levels were significantly increased in the olfactory epithelium of the COVID-19 group compared to the control group (P < 0.05). However, no differences in IL-1β were seen between groups. Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium in patients with COVID-19. This suggests that direct …
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