作者
Rachel M Brouwer, Marieke Klein, Katrina L Grasby, Hugo G Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I Thomopoulos, Emma Sprooten, Carol E Franz, Nitin Gogtay, William S Kremen, Matthew S Panizzon, Loes M Olde Loohuis, Christopher D Whelan, Moji Aghajani, Clara Alloza, Dag Alnæs, Eric Artiges, Rosa Ayesa-Arriola, Gareth J Barker, Mark E Bastin, Elisabet Blok, Erlend Bøen, Isabella A Breukelaar, Joanna K Bright, Elizabeth EL Buimer, Robin Bülow, Dara M Cannon, Simone Ciufolini, Nicolas A Crossley, Christienne G Damatac, Paola Dazzan, Casper L de Mol, Sonja MC de Zwarte, Sylvane Desrivières, Covadonga M Díaz-Caneja, Nhat Trung Doan, Katharina Dohm, Juliane H Fröhner, Janik Goltermann, Antoine Grigis, Dominik Grotegerd, Laura KM Han, Mathew A Harris, Catharina A Hartman, Sarah J Heany, Walter Heindel, Dirk J Heslenfeld, Sarah Hohmann, Bernd Ittermann, Philip R Jansen, Joost Janssen, Tianye Jia, Jiyang Jiang, Christiane Jockwitz, Temmuz Karali, Daniel Keeser, Martijn GJC Koevoets, Rhoshel K Lenroot, Berend Malchow, René CW Mandl, Vicente Medel, Susanne Meinert, Catherine A Morgan, Thomas W Mühleisen, Leila Nabulsi, Nils Opel, Víctor Ortiz-García de la Foz, Bronwyn J Overs, Marie-Laure Paillère Martinot, Erin B Quinlan, Ronny Redlich, Tiago Reis Marques, Jonathan Repple, Gloria Roberts, Gennady V Roshchupkin, Nikita Setiaman, Elena Shumskaya, Frederike Stein, Gustavo Sudre, Shun Takahashi, Anbupalam Thalamuthu, Diana Tordesillas-Gutiérrez, Aad van der Lugt, Neeltje EM van Haren, Joanna M Wardlaw, Wei Wen, Henk-Jan Westeneng, Katharina Wittfeld, Alyssa H Zhu, Andre Zugman, Nicola J Armstrong, Gaia Bonfiglio, Janita Bralten, Shareefa Dalvie, Gail Davies, Marta Di Forti, Linda Ding, Gary Donohoe, Andreas J Forstner, Javier Gonzalez-Peñas, Joao POFT Guimaraes, Georg Homuth, Jouke-Jan Hottenga, Maria J Knol, John BJ Kwok, Stephanie Le Hellard, Karen A Mather, Yuri Milaneschi, Derek W Morris, Markus M Nöthen, Sergi Papiol, Marcella Rietschel, Marcos L Santoro, Vidar M Steen, Jason L Stein, Fabian Streit, Rick M Tankard, Alexander Teumer, Dennis van ‘t Ent, Dennis van der Meer, Kristel R van Eijk, Evangelos Vassos, Javier Vázquez-Bourgon, Stephanie H Witt, Alzheimer’s Disease Neuroimaging Initiative, IMAGEN consortium, Hieab HH Adams, Ingrid Agartz, David Ames, Katrin Amunts, Ole A Andreassen, Celso Arango, Tobias Banaschewski, Bernhard T Baune, Sintia I Belangero, Arun LW Bokde, Dorret I Boomsma, Rodrigo A Bressan, Henry Brodaty, Jan K Buitelaar, Wiepke Cahn, Svenja Caspers, Sven Cichon, Benedicto Crespo Facorro, Simon R Cox, Udo Dannlowski, Torbjørn Elvsåshagen, Thomas Espeseth, Peter G Falkai
发表日期
2020/4/27
期刊
bioRxiv
页码范围
2020.04. 24.031138
出版商
Cold Spring Harbor Laboratory
简介
Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. While heritable, specific loci in the genome that influence these rates are largely unknown. Here, we sought to find common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association analysis of longitudinal changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 10,163 individuals aged 4 to 99 years, on average 3.5 years apart, were used to compute rates of morphological change for 15 brain structures. We discovered 5 genome-wide significant loci and 15 genes associated with brain structural changes. Most individual variants exerted age-dependent effects. All identified genes are expressed in fetal and adult brain tissue, and some exhibit developmentally regulated expression across the lifespan. We demonstrate genetic overlap with depression, schizophrenia, cognitive functioning, height, body mass index and smoking. Several of the discovered loci are implicated in early brain development and point to involvement of metabolic processes. Gene-set findings also implicate immune processes in the rates of brain changes. Taken together, in the world’s largest longitudinal imaging genetics dataset we identified genetic variants that alter age-dependent brain growth and atrophy throughout our lives.
One-sentence summary
We identified common genetic variants associated with the rate of brain development and aging, in longitudinal MRI scans worldwide.
学术搜索中的文章
RM Brouwer, M Klein, KL Grasby, HG Schnack… - bioRxiv, 2020