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Existing methods for information system (IS) project selection neglect an important aspect of information technology, namely the interdependencies that exist among various IS applications (projects). Recognizing and modeling these project interdependencies provides valuable cost savings and greater benefits to organizations. In this paper, an IS project selection model is developed that identifies and models benefit, resource and technical interdependencies among candidate projects. The proposed model is formulated as a nonlinear 0–1 programming problem and represents a significant addition to existing IS, capital budgeting and R&D project selection models. The model is converted, using linearization techniques, and tested (validated) by applying it to real-world IS project selection data. By comparing the performance of this model with existing project selection models, the contribution of this model is …