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Knowledge Management (KM) is becoming a growing concern in management research and practice because of its role in determining firm innovation capability and in enhancing working life quality of knowledge workers. This requires, even for Small and Medium Enterprises (SMEs) the creation of a sustainable work organization in terms of configuration of organizational and Information and Communication Technology (ICT) tools. With a particular emphasis in the area of Product Innovation (PI) and on the basis of a survey on 127 Italian SMEs, this paper aims at analysing the emergent technological and organizational approaches to managing knowledge in the PI process. Three different KM Configurations emerge: the `technical', the `relational' and the `advanced' approach.