作者
Kee-Hyun Paik, Yang Liu, Vincent Tabard-Cossa, Matthew J Waugh, David E Huber, J Provine, Roger T Howe, Robert W Dutton, Ronald W Davis
发表日期
2012/8/28
期刊
ACS nano
卷号
6
期号
8
页码范围
6767-6775
出版商
American Chemical Society
简介
We report the use of an array of electrically gated ∼200 nm solid-state pores as nanofluidic transistors to manipulate the capture and passage of DNA. The devices are capable of reversibly altering the rate of DNA capture by over 3 orders of magnitude using sub-1 V biasing of a gate electrode. This efficient gating originates from the counter-balance of electrophoresis and electroosmosis, as revealed by quantitative numerical simulations. Such a reversible electronically tunable biomolecular switch may be used to manipulate nucleic acid delivery in a fluidic circuit, and its development is an important first step toward active control of DNA motion through solid-state nanopores for sensing applications.
学术搜索中的文章
KH Paik, Y Liu, V Tabard-Cossa, MJ Waugh, DE Huber… - ACS nano, 2012