作者
Biao Huang, Xixi Cheng, Huafeng Wang, Wenjing Huang, Zha la Ga Hu, Dan Wang, Kai Zhang, Huan Zhang, Zhenyi Xue, Yurong Da, Ning Zhang, Yongcheng Hu, Zhi Yao, Liang Qiao, Fei Gao, Rongxin Zhang
发表日期
2016/12
期刊
Journal of translational medicine
卷号
14
页码范围
1-12
出版商
BioMed Central
简介
Background
Orthotopic liver transplantation is the only effective treatment for liver failure but limited with shortage of available donor organs. Recent studies show promising results of mesenchymal stem cells (MSCs)-based therapies.
Methods
We systematically investigate the therapeutic effects of MSCs or MSC-conditioned medium (MSC-CM) in ameliorating fulminant hepatic failure (FHF) and chronic liver fibrosis in mice. In addition, extensive flow cytometry analysis of spleens from vehicle and MSC- and MSC-CM-treated mice was applied to reveal the alteration of inflammatory state.
Results
In FHF model, MSCs treatment reduced remarkably the death incidents; the analysis of gross histopathology showed that control livers were soft and shrunken with extensive extravasated blood, which was gradually reduced at …
学术搜索中的文章
B Huang, X Cheng, H Wang, W Huang, Z la Ga Hu… - Journal of translational medicine, 2016