作者
Maaike H Oonk, Bettien M van Hemel, Harry Hollema, Joanne A de Hullu, Anca C Ansink, Ignace Vergote, René H Verheijen, Angelo Maggioni, Katja N Gaarenstroom, Peter J Baldwin, Eleonora B van Dorst, Jacobus van der Velden, Ralph H Hermans, Hans W van der Putten, Pierre Drouin, Ingo B Runnebaum, Wim J Sluiter, Ate G van der Zee
发表日期
2010/7/1
期刊
The lancet oncology
卷号
11
期号
7
页码范围
646-652
出版商
Elsevier
简介
Background
Currently, all patients with vulvar cancer with a positive sentinel node undergo inguinofemoral lymphadenectomy, irrespective of the size of sentinel-node metastases. Our study aimed to assess the association between size of sentinel-node metastasis and risk of metastases in non-sentinel nodes, and risk of disease-specific survival in early stage vulvar cancer.
Methods
In the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V), sentinel-node detection was done in patients with T1–T2 (<4 cm) squamous-cell vulvar cancer, followed by inguinofemoral lymphadenectomy if metastatic disease was identified in the sentinel node, either by routine examination or pathological ultrastaging. For the present study, sentinel nodes were independently reviewed by two pathologists.
Findings
Metastatic disease was identified in one or more sentinel nodes in 135 (33%) of 403 patients, and …
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MH Oonk, BM van Hemel, H Hollema, JA de Hullu… - The lancet oncology, 2010