作者
Gyorgy B Halmos, Tom P van der Laan, Bettien M van Hemel, Frederik G Dikkers, Lorian Slagter-Menkema, Bernard FAM van der Laan, Ed Schuuring
发表日期
2013/2
期刊
European Archives of Oto-Rhino-Laryngology
卷号
270
页码范围
719-725
出版商
Springer-Verlag
简介
The purpose of this study was to detect human papillomavirus (HPV) infection in laryngeal neuroendocrine carcinoma (LNEC) and to explore the possible relationship between HPV-induced malignant transformation and prognosis in LNEC. Ten cases of LNEC from a tertiary referral hospital were retrospectively analyzed. Clinical data were subtracted from patients’ files. Pretreatment biopsy material was tested for the presence of HPV6, 11, 16, and 18 using a PCR-based detection method. Immunohistochemical staining was performed for Ki-67, p16INK4A, and p53 expression. All cases were negative for the low-risk HPV types HPV6 and HPV11 that are associated with laryngeal papillomatosis. High-risk HPV was detected in two cases; an atypical carcinoid was positive for HPV16 and a large-cell neuroendocrine carcinoma for HPV18. Both HPV-positive tumors had a high Ki-67 labeling index. Two of the …
学术搜索中的文章
GB Halmos, TP van der Laan, BM van Hemel… - European Archives of Oto-Rhino-Laryngology, 2013