作者
Sanne van der Mark, Peter Klaver, Kerstin Bucher, Urs Maurer, Enrico Schulz, Silvia Brem, Ernst Martin, Daniel Brandeis
发表日期
2011/2/1
期刊
Neuroimage
卷号
54
期号
3
页码范围
2426-2436
出版商
Academic Press
简介
Developmental dyslexia is a severe reading disorder, which is characterized by dysfluent reading and impaired automaticity of visual word processing. Adults with dyslexia show functional deficits in several brain regions including the so-called “Visual Word Form Area” (VWFA), which is implicated in visual word processing and located within the larger left occipitotemporal VWF-System. The present study examines functional connections of the left occipitotemporal VWF-System with other major language areas in children with dyslexia. Functional connectivity MRI was used to assess connectivity of the VWF-System in 18 children with dyslexia and 24 age-matched controls (age 9.7–12.5years) using five neighboring left occipitotemporal regions of interest (ROIs) during a continuous reading task requiring phonological and orthographic processing. First, the results revealed a focal origin of connectivity from the VWF …
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