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Chronic liver disease (CLD) in the clinical context is a disease process of the liver that involves a process of progressive destruction and regeneration of the liver parenchyma leading to fibrosis and cirrhosis. It refers to disease of the liver which lasts over a period of six months. It consists of a wide range of liver pathologies which include inflammation (chronic hepatitis), liver cirrhosis, and hepato-cellular carcinoma. Portal hypertension is the earliest and most important consequence of cirrhosis and underlies most of the clinical complications of the disease. This study was carried out at AMRI hospital, Bhubaneswar to find the prevention of CLD by applying therapeutic diet. About 30 patients were chosen as a subject and analyzed in respect to their anthropometric, nutritional and bio-chemical parameters. In the study of anthropometric assessment it was found that CLD patients had lower BMI and MUAC level than standard level. The BMI and MUAC of CLD patient was found 19.66±0.202 and 21±0.967 respectively. The values were found significantly differ from the reference standard value with F-value for BMI and MUAC was 1.69 and 0.033 respectively at p< 0.001, where as in biochemical assessment it was found that CLD patients had lower level of albumin and higher level of bilirubin, SGOT and SGPT than normal level. The SGOT and SGPT of CLD patient was found 46.4±0.008 and 51.7±0.031 respectively. The values were found significantly differ from the reference standard value with F-value for SGOT and SGPT was 5.813 and 3.970 respectively at p< 0.001. During the analysis of nutritional assessment it was found that CLD patients …