作者
Jing Sun, Ryan J Longchamps, Damani A Piggott, Christina A Castellani, Jason A Sumpter, Todd T Brown, Shruti H Mehta, Dan E Arking, Gregory D Kirk
发表日期
2019/4/8
期刊
The Journal of Infectious Diseases
卷号
219
期号
8
页码范围
1285-1293
出版商
Oxford University Press
简介
Background
Low mitochondrial DNA (mtDNA) copy number (CN) is a predictor of adverse aging outcomes, and its status may be altered in human immunodeficiency virus (HIV)–infected persons. This study evaluated the cross-sectional and longitudinal change of mtDNA CN by HIV markers.
Methods
mtDNA CN was measured in the ALIVE (AIDS Linked to the Intravenous Experience) cohort of persons with a history of injecting drugs. Multivariable linear regression models controlling for demographic characteristics, behavior, and hepatitis C virus (HCV) seropositivity assessed the relationship of mtDNA CN to HIV markers (CD4+ T-cell counts, viral load, antiretroviral therapy [ART] use). Linear mixed models tested the association between HIV markers and age-related mtDNA CN trajectories.
Results
Among 741 individuals at baseline, 436 (59%) were …
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J Sun, RJ Longchamps, DA Piggott, CA Castellani… - The Journal of Infectious Diseases, 2019