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In the agribusiness wine is certainly a very interesting sector to analyze. The specific aim of this work is to assess water efficiency and economic water productivity for the Italian wines with Appellation of Origin (AO). This assessment could represent a potential management instrument to improve production performances from a more integrated perspective, pursuing new market trends. The study is related to Italy, the first worldwide producer, and analyzes the available data of AO wines, which globally have specific features, being strictly connected with the territory and its background. The results show the top and bottom five AO wines in terms of crop water use and economic water productivity and their trends during the period 2011–2015, based on average annual change rates. Results of this study are relevant for the wine sector since they can guide decision makers on vine variety selection in the context of micro …