作者
Davide Anchisi, Barbara Borroni, Massimo Franceschi, Nasser Kerrouche, Elke Kalbe, Bettina Beuthien-Beumann, Stephano Cappa, Olaf Lenz, Stephan Ludecke, Alessandra Marcone, Rüdiger Mielke, Paola Ortelli, Alessandro Padovani, Oriana Pelati, Alberto Pupi, Elio Scarpini, Simon Weisenbach, Karl Herholz, Erik Salmon, Vjera Holthoff, Sandro Sorbi, Ferruccio Fazio, Daniela Perani
发表日期
2005/11/1
期刊
Archives of neurology
卷号
62
期号
11
页码范围
1728-1733
出版商
American Medical Association
简介
Background
Subjects with amnesic mild cognitive impairment (aMCI) may include patients at high risk for progression to Alzheimer disease (AD) and a population with different underlying pathologic conditions.
Objective
To evaluate the potential roles of positron emission tomography with fluodeoxyglucose F 18 (18FDG-PET) and memory scores in identifying subjects with aMCI and in predicting progression to dementia.
Design, Setting, and Patients
Sixty-seven patients at European centers for neurologic and AD care who were diagnosed as having aMCI each underwent an extensive clinical and neuropsychological examination and an18FDG-PET study. Forty-eight subjects were followed up periodically for at least 1 year, and progression to dementia was evaluated.
Main Outcome Measures
Brain glucose metabolism and memory scores.
Results
Fourteen subjects with aMCI who converted to AD within 1 year showed …
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