作者
Bruno Memoli, Loredana Postiglione, Bruno Cianciaruso, Vincenzo Bisesti, Cristina Cimmaruta, Luigi Marzano, Roberto Minutolo, Vincenzo Cuomo, Brunella Guida, Michele Andreucci, Guido Rossi
发表日期
2000/7/1
期刊
Kidney international
卷号
58
期号
1
页码范围
417-424
出版商
Elsevier
简介
Role of different dialysis membranes in the release of interleukin-6-soluble receptor in uremic patients.
Background
Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated proteins. The sIL-6R binds the ligand IL-6 with comparable affinity as the membrane-associated IL-6R and enhances the actions of IL-6.
Methods
Our aim was to evaluate the role of both uremia and different dialysis membranes on peripheral blood mononuclear cell (PBMC) release (either in absence or in presence of mitogen stimulation) and plasma levels of sIL-6R. Ten patients chronically dialyzed with cuprophan membranes (CU), eight patients on regular dialysis treatment with …
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B Memoli, L Postiglione, B Cianciaruso, V Bisesti… - Kidney international, 2000