作者
Joseph Sriyal Malik Peiris, Chung-Ming Chu, Vincent Chi-Chung Cheng, KS Chan, IFN Hung, Leo LM Poon, Kin-Ip Law, BSF Tang, TYW Hon, CS Chan, KH Chan, JSC Ng, BJ Zheng, WL Ng, RWM Lai, Y Guan, KY and Yuen
发表日期
2003/5/24
期刊
The lancet
卷号
361
期号
9371
页码范围
1767-1772
出版商
Elsevier
简介
Background
We investigated the temporal progression of the clinical, radiological, and virological changes in a community outbreak of severe acute respiratory syndrome (SARS).
Methods
We followed up 75 patients for 3 weeks managed with a standard treatment protocol of ribavirin and corticosteroids, and assessed the pattern of clinical disease, viral load, risk factors for poor clinical outcome, and the usefulness of virological diagnostic methods.
Findings
Fever and pneumonia initially improved but 64 (85%) patients developed recurrent fever after a mean of 8.9 (SD 3.1) days, 55 (73%) had watery diarrhoea after 7.5 (2.3) days, 60 (80%) had radiological worsening after 7.4 (2.2) days, and respiratory symptoms worsened in 34 (45%) after 8.6 (3.0) days. In 34 (45%) patients, improvement of initial pulmonary lesions was associated with appearance of new radiological lesions at other sites. Nine (12%) patients …
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JSM Peiris, CM Chu, VCC Cheng, KS Chan, IFN Hung… - The lancet, 2003