作者
Man–Fung Yuen, Danny Ka–Ho Wong, James Fung, Philip Ip, David But, Ivan Hung, Kevin Lau, John Chi–Hang Yuen, Ching–Lung Lai
发表日期
2008/10/1
期刊
Gastroenterology
卷号
135
期号
4
页码范围
1192-1199
出版商
WB Saunders
简介
BACKGROUND & AIMS
Our aims were to study the virologic, histologic, and clinical outcome in chronic hepatitis B (CHB) patients with hepatitis B surface antigen (HBsAg) seroclearance.
METHODS
We determined the age of HBsAg seroclearance that is associated with a lower risk for the development of hepatocellular carcinoma (HCC) in 298 CHB patients (median follow-up, 108 months). The following virologic and histologic features after HBsAg seroclearance were also determined: liver stiffness (n = 229), liver histology (n = 26), serum HBV DNA levels over time (n = 265), intrahepatic HBV DNA with covalently closed circular DNA (cccDNA) levels (n = 29), and messenger RNA (mRNA) expression (n = 11).
RESULTS
The median age of HBsAg seroclearance was 49.6 years. Seven (2.4%) patients developed HCC. Cumulative risk for the development of HCC was higher in patients with HBsAg seroclearance at …
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