作者
Kelvin KW To, Ivan FN Hung, Iris WS Li, Kar-Lung Lee, Chi-Kwan Koo, Wing-Wa Yan, Raymond Liu, Ka-Ying Ho, Kwok-Hong Chu, Chi-Leung Watt, Wei-Kwang Luk, Kang-Yiu Lai, Fu-Loi Chow, Thomas Mok, Tom Buckley, Jasper FW Chan, Samson SY Wong, Bojian Zheng, Honglin Chen, Candy CY Lau, Herman Tse, Vincent CC Cheng, Kwok-Hung Chan, Pandemic H1N1 Study Group, Kwok-Yung Yuen
发表日期
2010/3/15
期刊
Clinical Infectious Diseases
卷号
50
期号
6
页码范围
850-859
出版商
The University of Chicago Press
简介
Background. Infections caused by the pandemic H1N1 2009 influenza virus range from mild upper respiratory tract syndromes to fatal diseases. However, studies comparing virological and immunological profile of different clinical severity are lacking.
Methods. We conducted a retrospective cohort study of 74 patients with pandemic H1N1 infection, including 23 patients who either developed acute respiratory distress syndrome (ARDS) or died (ARDS-death group), 14 patients with desaturation requiring oxygen supplementation and who survived without ARDS (survived-without-ARDS group), and 37 patients with mild disease without desaturation (mild-disease group). We compared their pattern of clinical disease, viral load, and immunological profile.
Results. Patients with severe disease were older, more likely to be obese or having underlying diseases, and had lower respiratory tract symptoms …
引用总数
学术搜索中的文章
KKW To, IFN Hung, IWS Li, KL Lee, CK Koo, WW Yan… - Clinical Infectious Diseases, 2010