作者
Madhavi Eerike, Gerard M Raj, Rekha Priyadarshini, Gandham Ravi, Debasis Bisoi, Venu GR Konda
发表日期
2022/6/1
来源
Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders)
卷号
22
期号
4
页码范围
19-32
出版商
Bentham Science Publishers
简介
Ivermectin (IVM), an approved anthelminthic drug, has been reported to have antiviral, antibacterial, and anticancer activities. Antiviral activity is due to the inhibition of nuclear cargo importin (IMP) protein. The anti-SARS CoV-2 activity through in vitro study was first reported by an Australian team. Later, many studies were conducted, and most of the study results were available as non-peer-reviewed preprints. In this narrative review, literature on the clinical studies conducted with ivermectin from published articles, preprints, and unpublished evidence was collected until 13th June 2021. They are discussed based on the severity of COVID-19 disease. Out of the 23 peer-reviewed published articles, 13 studies were randomized controlled trials. The remaining were either prospective interventional, prospective observational, retrospective cohort, cross-sectional, or case series type of studies; additionally, there were 10 …
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M Eerike, GM Raj, R Priyadarshini, G Ravi, D Bisoi… - Infectious Disorders-Drug Targets (Formerly Current …, 2022